Blade can do no more than a flesh wound on Drax with his best thrust, and that's being generous.
Drax was able to tank Yondu's arrow shooting into him with some pain but it didn't seriously wound him. Considering all of his other rather impressive durability feats for a character of his weight class and Blade won't be outlasting him.
Blade is one of my favorite on-screen superheroes to date - even 21 years later - and while his feats are outstanding and over-the-top compared to even some modern movie street-levelers, Drax's re-entry feat is too much for Snipes to handle. Yes, Blade can speed blitz him, but I think Drax is too much brick here.