Peter webbing him up would probably work if we consider how much trouble the Cloak of Levitation gave him. But yeah, I don't think Spidey has shown the actual striking power to KO Drax yet. Drax gets murked in round 2 if Peter's spider legs can pierce him though. They are way too fast. Those things one-shotted like a dozen Outriders in like 2 or 3 seconds during Endgame.