Five Biggest guns in Comics

Just recently a newly resurrected Dione went down like a chump, and it's not even the first time he gets wtf-pwned by unconventional weaponry.

List your top 5 weapons that any one chump could use to deal with a much more powerful individual. No weakness explotation.

If you have a weapon that has a built in plot device like "it kills anything" you need to provide its high end feats, not just back it with an statement.

1. Saint of Killer's guns (kills *anyone*, up to and including God)
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rest

Edit. scans:
http://heroesvillainsandsidekicks.com/wp-content/uploads/2017/07/RCO020_1469407060.jpg
http://heroesvillainsandsidekicks.com/wp-content/uploads/2017/07/RCO024_1469407060.jpg

Originally posted by Magnon
1. Saint of Killer's guns (kills *anyone*, up to and including God)

It also failed to one-shot a few random soldiers here and there. It was also explicitly stated it'll fail vs god in his throne.

Originally posted by Galan007
Except vampires. 😉

0. Count Dracula's adamantium katana (kills *anyone*, up to and including vampires)
1. Saint of Killer's guns (kills *almost anyone*, up to and including God)
.
.
.
rest

Crimson Avenger's guns? Best feat I've seen is her taking down Captain Atom with them...

https://imgur.com/a/CEcHE

The New God "essence of bullet" that Darkseid fired through time was pretty neat:
https://i.imgur.com/sZnvUj8.jpg
https://i.imgur.com/upKS43l.jpg

I guess I'll nominate Reed's Celestial Busting gun.