Only issue for the Riders is if Wolf decides to go into stealth mode, because while they had some level of preternatural perception IIRC, it was focused on supernatural-related stuff. So, it probably won't help them tracking a Predator. But, as I said, the Riders are too hard to inflict permanent damage on. Even in human form, Reyes has managed to remain conscious after being repeatedly impaled and dosed with enough radiation to kill several people multiple times over.