Mr. Sinister would have to leave his body to defeat Man Thing.
A lot of telepaths can do that even though the Professor can't.
If Mr. Sinister let Man Thing assume control of his body he could snatch all the tones that Man Thing can teleport to makeing beautiful Sinister music out of it.
In effect he would assume control of Man Thing's locations and could concievably drive him crazy through teleportation like Jeff Goldbloom went a little off the wall in The Fly.