Bumblebee (Transformers Bumblebee 2018 film) vs. Spider-Man (MCU)
It's Big vs. Small, as two young, bug-themed heroes, who're both seen as the younger members of a group of heroes, were taken in an apprentice towards a red armored hero, and are arguably the most marketable in their respected heroes, are about to clash in a fight to the death.
Battle Location: City of Chicago.