obviously this is a one sided match up. especially when you start adding all of the x-men together.
But there was a time when Spidey fought a 4+ x-men at once and danced circles around them. I don't have the comic, but it was referenced in one of the threads from a couple of months ago.
I'm like 90% sure it was in the Original Secret Wars. Because Spidey was part of Captain America's team, and the X-men were like the 3rd "neutral" team.
I know Colossus, Wolverine, and Storm were part of the group. i'm pretty sure Cyclops was involved too.
Spiderman kicks ass. he's not one of Marvel's best heroes for no reason. He would take out a few x-men before he was down for the count.