errrrrrr i DONT THINK SO! lmoa, this is ridisulously funny. do you have any idea how many time you have to DIE and be reborn in metal slug x to complete the damn thing?! and there are ZOMBIES too, and we know dam,n well that big boss pisses his pants at the mention of dracula and zombies{play the nightmare mini game in metal gear snake eater}. besides, the players in metal slug can drop from PHENOMENON heights unharmed{or just die and be born again after wasting one life} like straight from the sky. and i doubt any1 can avoid the sheer amoung of fire/bombs/explosion and crazy large techno goth machines with lazers and rockets and god knows what else. so no, big boss doesnt stand a CHANCE!
what the...? I thought he's supposed to fought entire MSX character from marco to fio... so, this thread was just asking could naked snake survive in MSX style?
dude, that's all in-game mechanics. its not like Fio and the rest can rejuvenate. also all you really need to do is cross the country shooting people with infinite ammo and people tossing you food and some half naked Ryu-guy who does hadoukens to help ya out. on top of that you get to sit in tanks and jets. sure big boss can do it. heck, knowing him he'd probably disguise as a box and waltz through to the end boss