Hades is like a long term marriage, it takes forever to make any real progress.
My first clear was... 25-30 runs maybe? I'm almost up to 50 now and closing in on my first "heat"; which is just a fancy way of saying an added difficulty clear with one of several handicaps that have a heat element attached to them, like more health for bad guys or new attacks, taking more damage ect.
All online guides are useless because they assume fully decked out unlocks. Each unlock uses between 1-4 of a currency called Titan Blood, and you get only 2 Titan bloods per entire runs per weapon, out of six weapons. You can also buy more of it but that takes other currencies which means more runs for grinding them up.
I hate looking up guides because everyone insists 30 heat is easy or some stupid shite. Yeah no, when you say it took 400 hours to get where you are that ain't easy.
More or.less all Rogue Likes are this. Dead Cells, Darkest Dungeon, FTL Faster Than Light, it's all OCD people.who clear it fast. For the rest of us its a good fun game in spurts.