Maybe I'm wrong, but I have the impression some people here are hoping for too much. Venom, Carnage, Lizard, the Hulk, guest appearances from other superheroes/villains, even from the DC universe instead of the Marvel Universe...
It sounds to me like a far fetched wishing list.
So I want to say the following: I don't like the idea of making a movie about Spider-Man and then letting him fight all the time with some super powered freak like Venom and at least one other infamous villain at the same time. What's the point ?
Spider-Man is a hero, he saves lives. That is what he does. He saves the lives of men and women, gets people out of burning buildings, solves a murder (from time to time), deals with bank robbers, helps when there's some kind of accident, goes in search for lost girls who are kidnapped, prevents people from getting robbed, is almost arrested by the police and even sometimes saves a kitty out of a tree 🙂.
If I would direct Spider-Man 2 (yeah right) I would focus more on the human aspect of Spider-Man, and a little bit less on those big fights with explosions everywhere and with lots of (collateral) damage. Just having him fight every Spider-Man foe only to please the comic fans degrades Spider-Man, in my opinion. He deserves better. Of course, he has to fight some villain from time to time (hopefully Venom one day) but again, that's only a small part of the story, if you ask me.
Sometimes I get the impression that some superheroes were only created to fight super villains, who of course were only created to fight superheroes. I don't want to see this happen to Spider-Man.
Mind you, I'm as curious as the next guy about seeing Venom and company in the movies, believe me, but being Spider-Man is lots more than fighting his super powered enemies.