Originally posted by xmarksthespot
Easiest way would be to drop him in a vat of pH 0.1 acid or pH 10 alkali. Negates the healing factor since that requires protein (I think) and extremes of pH cause improper protein fold. Wolverine dissolves.
Yes his protein would be denatured, however he has survived his flesh being pretty much burnt off - I don't know we can look for sane answers.