Having Venom murder a pregnant Mary Jane or Aunt May in public would set the stage for the ultimate fight scene (I know, I know, a pathetic and cliched attempt at inducing pathos). Peter (as Spiderman should arrive mere moments after Eddie has killed her. Meanwhile several bombs are going off in selective buildings, courtesy of the Hobgoblin. Pete is faced with another moral dilemma kill the animal who killed his wife and unborn son or save the lives of thousands of innocents by handing Harry his ass. To make things worse, one of Harry's bombs blows up a gas main which in turn decimates the entire city block. Hundreds of people are killed in the process and the street is now covered in flames. Peter, for some reason rips the spider insignia off of his chest revealing a picture of his Uncle Ben and Aunt May. He then dashes for Venom who has now been weakened by the flames but still maintains a decent amount of tenacity. They fight as tears pour from Peter's eyes, Mary Jane dead, hundreds of innocents dead and he feels wholly responsible. Peter pounds on Venom ferociously. He grabs nearby stones and shrapnel to tear at Eddie. Harry attacks from behind and Peter responds by quickly ripping the wiring from his pad and ripping his heart from his chest. He has never displayed this much speed, strength or ruthlessness. He continues to pound Venom until he sees them. His parents, Uncle Ben, Otto Octavius, Norman Osborne and Norman Osborne even Mary Jane and his unborn son. They tell him it isn't his fault but he can't hear them, they drowned out by his ranting consciousness, its pitch potent enough to shatter bulletproof glass. He hits and hits until nothing is left of Eddie, save a bloody swollen corpse and black puddle with a white streak. He stands amidst the disaster area, sheds his costume and lies down beside the burnt corpse of Mary Jane and allows the flames to consume him. Fade to black.
P.S. Morbid is my middle name. 😄