Ill await for someone come up with how Reed would take him in a straight brawl, without any prep.
I see Herc taking the others, especially because theres nothing indicating - yet - that She Hulk is stronger than Immortal Hercules. Hes also more skilled than his opponents, being Thing the closest they got on that level.
Taking Sue out its going to be the problem, thats why i also asked about her shields.
This is how the fight would go:
First, reed would get close to him and try to reason with him, and Herc would hit him once and knock him out. Then Herc, since he knows how to fight very well, would realize that his biggest threats are the Thing and She-Hulk, so he would go after them, knocking them each out in one or two hits. Then he would go after the Human Torch, who would probly go airborne. using his incredible leg strength, herc would jump up, grab HT, and take a nosedive back down to the ground with him on his shoulder. Then comes the Invisible Woman. I dont think breaking through her shields would be that much of a problem once the others are knocked out, because it'll take time for him to bust through so if he tried to get to her first, he could be left open for attack by the other 4 while hes trying to break threw her shield, which is why he would save her for last.