Surfers had it pretty bad.
-He gave up his life(and his love) to become Galactus's herald.
-Finally got free from Galactus, at the cost of being stuck on Earth.
-He's lost Mantis, Nova, and Shalla Bal, on numerous occasions.
-He's hated in quite a few places through out the universe, for ever being Galactus's herald.
-He spends most of his time wanting to be left alone, but he gets pulled into just about every cosmic level conflict that happens.
-He's unfortunate enough to just about always be the one who stumbles on cosmic level villains plots to take over everything.
-And Mephisto has just about made capturing Norrin's soul, his ultimate objective.
Other heroes may have had it as bad or worse, but probably not many.