With the Sinestro Corps, Cyborg Superman, Parallax, SB Prime, Anti-Monitor, Monarch, Darkseid, etc etc etc....I kind of have a feeling that we're going to see some villains as heroes. The scales are too far tipped on their side for the heroes to be able to combat such a strike.
Parallax: I think Kyle's just going to break the hold. He's their "torchbearer" and they mention it constantly. If anyone could, it'd be him.
Sinestro Corps: All these new ones coming out, with Star Sapphire and everything, I sense a rainbow war lol.
Anti-Monitor: We've seen the Monitors hard at work trying to fix the multiverse and actually being forceful. Maybe they'll come to their senses and focus their attack on AM rather than Dick Grayson lol.
Cyborg Superman: He's really no more of a threat than normal, basically, but that's not counting him out. He's still powerful as hell. Not sure how they'll deal with him.
SB Prime: This guy you've got to watch out for if he's even more powerful than before. They built him up to be ridiculously powerful.
Darkseid: They haven't released enough of his plans yet for me to really draw any conclusions. However, I know Darkseid wouldn't appreciate it if he was eradicated from existence.
Monarch: I just really have a feeling that Captain Atom is in anti-hero mode. He was in the Bleed so the Monitors wouldn't watch him, right? You can't dismiss the "deep down, he's still a good guy" element in storylines, so I just think that he's going to come to his senses and whoop some people - maybe that's who they'll use for SB Prime's defeat.
Right now, the villains have it all. All they need is Doomsday, Imperiex, and Brainiac, and its over lol. Its either going to end in an amazing way or a total disappointment.