Originally posted by Scythe
Thank you. Equipping a weapon's ultimate form to a custom character will help unlock more items?
No, but those are some of the best items in the game. What more could you want? I mean, what kind of items are you looking/aiming for? Well, there are some rare ones that can be acquired in the Tower of Lost Souls, especially in Descending mode, which can be unlocked after you get past the 20th floor in Ascending.