I'm probably just a bit too tired now but reflecting on it, Fallout 3 is like an uber depressing game.
Spoiler:
Let's reveiw.You start the game and pick sex/apperance, your mother then dies.
You have a birthday party, in which a bully will either: take your present, beat you up, or promise to beat you up later, you are at this point 10 years old.
Your father abandons you and leaves you in a Vault alone until the end of time(or so he planned). Meanwhile the Overseer decides he's going to kill you. (I tried to surrender the first time around, and he'll try to beat you to death with any weapons you gave him)
The world is as it is in the game. Generally filled with nasties, you have to treck across the barren wasteland after your father as you literally have nothing else.
After you finally catch up to him, after going through a very resident evil or, dawn of the dead kind of experience all he does is question why you left the vault
You work together on your mothers dream (something good? .... wait for it)
Your father is killed.
(Optional) You get a distress signal from the vault your best friend is begging for help. Assuming you go back, you find the overseer wants to keep everyone locked away forever, or rather for the next 2 (max) generations. Or do what Amata wants and let them open the vault for trading etc, though that means opening the doors to the horrors too. No matter what you decide you will never be allowed back again.
You get kidnapped by the Enclave and asked to kill thousands or more for the sake of killing all of the bad guys aswell. Thus utterly tainting your mothers dream.
You choose, either to Sacrifice yourself for your mothers dream, but it's nicely stated that ultimately nothing's changed. Or make someone else do it and they get all the credit.
That ending was a bummer, after all of the story i thought there had to be a cliche rainbow at the end ^^' Apparently not though.