Increased muscle mass at such a young age can lead to skeletal deformities, as well as the risk of slowed learning due to half the body fat compared to an average child.
'One possible concern, according to Dr. Markus Schuelke, the pediatric neurologist at Charite University Medical Center in Berlin who discovered the myostatin mutation in the baby, is that blocking myostatin could interfere with satellite cells that help replace injured or dead muscle cells. It's thought that myostatin helps keep the satellite cells at rest until they're needed, and it's possible that without myostatin the satellite cells could become depleted.
Meanwhile, some say myostatin blockers may be too targeted to boost muscle growth, as there are a variety of proteins similar to myostatin that also limit muscle growth.
Another drug company, Acceleron Pharma, is planning to test a drug on humans that reportedly blocks not just myostatin but also many of the other similar proteins.'
It's going to be interesting keeping up with what happens to this child.
Apparently they are also looking in to developing myostatin blockers as a new form of steroids. I cant believe this shit, already they are looking to exploit it. 🙄
Originally posted by Da Joker...Did you just insult him for doing a mom joke, then made a mom joke to insult him? 😐
I'm not a bigot, and nice comeback with the mom joke. Really shows the intelligence coming off of you.I bet your mom's some hick who got sexed up by her dad and had you. STOP INBREEDING! IT'S NOT COOL!
Your fail levels are reaching levels to high. You must stop posting on the internetz or else your fail level will eventually corrupt and destroy it.
Oh, and as for you not being a bigot, lol, you claimed gays get sent to hell and castrated and said men that don't like women are not real men at all. Lol. Bigot.
And as for this thread...Yeah the kid seems to be pretty super for a human. Though as Kosta pointed out later he may be affected by it negatively.
Originally posted by Kosta
'One possible concern, according to Dr. Markus Schuelke, the pediatric neurologist at Charite University Medical Center in Berlin who discovered the myostatin mutation in the baby, is that blocking myostatin could interfere with satellite cells that help replace injured or dead muscle cells. It's thought that myostatin helps keep the satellite cells at rest until they're needed, and it's possible that without myostatin the satellite cells could become depleted.
Does that doctor have any studies to show for that information? Professional opinion is great and all, but an actual legit study or two would be much much better. I'm getting a different story. Such as POTENTIAL weakening(or weaker, relative to the "average"😉 of connective tissues (tendons). I've posted my sources already for my information. It would be nice if your doctor had some. If it's just a guess on the doctor's part, great...there's plenty of other mammals out there who are similarly affected by the lack of myostatin as this child. Maybe she could study those animals and see if her ideas have credibility?
Originally posted by Kosta
Meanwhile, some say myostatin blockers may be too targeted to boost muscle growth, as there are a variety of proteins similar to myostatin that also limit muscle growth.
The inhibitive effects of the myostatin gene expression is pretty straight forward. Sure, there's a myriad of other factors involved in muscular hypertrophic suppression, but myostatin's role is pretty straight forward. So, are those "some" that you're listening to basing what they say on sound science? A quick search on myostatin would net you contradictions, of course.
Originally posted by Kosta
Another drug company, Acceleron Pharma, is planning to test a drug on humans that reportedly blocks not just myostatin but also many of the other similar proteins.'
ACE-031, to be exact. It's primary method of effectiveness(I swear, there's a technical term for those last three or four words...I just can't remember it off the top of my head 🙁 ) is most likely myostatin inhibition. There's quite a few things that could be targeted to help enhance muscle growth, but myostatin inhibition seems to be absurdly effective. We could go on all day about all the different little things the body does to positively and negatively affect muscular hypertrophy. There's a multi billion dollar supplement industry out there exploiting them to some degrees. 😉
I'm not too sure but I thought it was much much harder to measure a drug's effectiveness (any pharmaceutical counteractions that might occur, toxicity that manifests between two different drugs simultaneously doing their modulation thang, etc.) to make excellent measurements of the effects of the pharmaceuticals, and getting it FDA approved. It's not the same as binding the active ingredient to a sustained release system and getting yourself another 15 years of exclusivity on the "new" form.
I'd like to know more about the contents of this drug, but I don't expect much because those drug companies like to keep that shit tight lipped to keep others from developing similar items before the "originals" are done.
Originally posted by Kosta
It's going to be interesting keeping up with what happens to this child.
So, do we have manifestations in any form of deformed bones or diminished cognitive abilities? (relative to the population, of course!) He's 4 now, isn't he? Surely that's more than old enough to observe these types of negatives?
Originally posted by Kosta
Apparently they are also looking in to developing myostatin blockers as a new form of steroids. I cant believe this shit, already they are looking to exploit it. 🙄
That last part was misplaced fear mongering. Don't fall victim of the 'steroid fear craze", please. You're much worse off smoking a pack a day then intelligently running testosterone ethanate through your body in cycles ("intelligently" implies that you're watching out for aromitization, can't be having too much estradiol, right?) . Seriously. In fact, in some cases (could be a "most" in America), doing the latter could actually improve health. EGADS! But steroids are bad for you, aren't they? pppffffffffff
Back on topic, what exactly is wrong with taking a drug that inhibits one of the major elements that puts a nice death grip on muscular hypertrophy that has shown little side effects in human clinical trials? You do know that they have some in clinical trials now, don't you?
Here's one that I found in a split second.
http://www.medicalnewstoday.com/articles/20441.php
I've read about these clinical trials. (I could be reading about the same pharmaceuticals, though.) They seem very promising. Almost too good to be true. All the benefits of anabolics with little to no side effects? Sign me up when the cookies are DONE! 😄
Spoiler:
And, no, I don't take any anabolic steroids, HGH, etc. in anyway shape or form. Waaay too damn expensive...and I don't want to have to mess with shit like cycles, injections, clomid and on and on and on. Side effects are not really appealing anyway.
BTW. "Flex" Wheeler has a myostatin "problem": he doesn't produce very much of it. He's never torn a muscle, though I'm not sure this "tendon" problem is that much of a "problem". However, I'll remain skeptical until I have better concrete data.
P.S. If there's mistakes in this post, great. I didn't bother proofreading . I've also taken some liberty on "common knowledge" that is not "common knowledge" at all. Google can make it "common" if used, though.
Originally posted by Da Joker
I can do this stuff, because I'm me. If you guys don't like me I'm not forcing you to respond. But the more you do, the more stupid and utterly ridiculous claims I'll make.The sky is red. **** that blue sky shiznit, it's red.
And then eventually you'll just get banned.
So I suppose we should keep on then. 🙂