What If... Batman and Robin actually were gay?
All the old jokes aside, in this universe Batman and Robin are actually gay. What happens when their relationship is revealed to the world? Now Batman wants Robin on the League and won't take no for an answer. Wonder Woman is surprisingly supportive, saying "there should be more of us... er, I mean more gay/lesbian people on the team". Kansas farm boy Superman is not so sure... leading to another hilarious Batman-Superman showdown.
What If... J. Jonah Jameson revealed that Spider-Man was a mutant?
For years J. Jonah Jameson has maligned Spider-Man in the Daily Bugle, smearing him a menace and blaming him for everything from vigilantism and crimes to sabotage. He even hired villains and robots to capture or kill Spider-Man. But it's not enough. In this universe, Jonah takes note of the anti-mutant hysteria sweeping the country. Although not buying into it himself, he realizes he can use it - the next day he publishes an expose "revealing" Spider-Man to be a mutant.
Spider-Man denies it, but other than specialists like Xavier or Sentinels, few people have any means of distinguishing mutants from other super-beings. Now the general public hates Spider-Man as a "mutant scum" despite being mostly okay with him previously. Even worse, X-Villains start coming after him, and despite his best efforts he finds himself unwillingly drawn into constant, never ending, and tedious X-storylines...