Now that Fender and Eastwood have gotten sucker, Nintendo feels like the most lefty friendly large company. Link, Pit, and maybe Samus make me feel accepted every time I think back to embarrassingly smudging writing on a chalkboard or freaking out a girl I was making out with by being on the wrong side of the couch.
Classic Link = Awesome.
(Image may or may not be stolen from Cyner, who may or may not have stolen it from the 1980's game manual, which may or may not be poorly translated.)
My personal favourite is OoT Link.
His life gets pretty wrecked in a real hurry, twice. But he keeps on saving people anyway. Most people would have just let Hyrule or Termina burn at that point.