Depends. If "hurt" means cause Juggernaut to register pain then maybe - I've seen Juggs apparently register pain on several occasions even though he wasn't actually harmed (and it was probably bad writing anyway).
If it means cause any sort of actual physical damage then no, I don't think regular Superman can do it.
But if you are talking strongest version of Superman it's a different ballgame. I don't know what the consensus is in placing beings like Supes 1 Million, peak SB Prime, peak sundipped gold Prime, cosmic armor etc in relation to skyfathers (or each other) and whether they have enough power to overcome the enchantment.