Well, i guess if you take it ultra-literally, that the simplest solution that accounts for ALL variables is the correct one, but then I think the principle loses its punch.
Take a Rube Goldberg machine, its certinaly not the most efficient way to accomplish a task, but it likely is "the simplest" if you accout for having to include a burning piece of paper, a bowling ball, and a squirt gun filled with vinegar. Unfortunately biology reminds me of rube goldberg a lot, just with motifs.