Lord Lucien
Lets all love Lain
In no particluar order, there are a number of instances where combat is forced on you, and you can't proceed until you've killed someone that no random NPC can do for you. These are all initiated via cutscene:
You "have" to kill several dozen Sith troopers as you leave Paragus.
The fake Batu Ram.
The twin Twi'lek bounty hunters.
The crew of the crashed Duros ships.
Three Dark Jedi Masters in Freedon Nadd's tomb.
The drexl in the Iziz Palace.
About a dozen Vaklu supporters when you crash the Basilisk in the city.
Another Dark Jedi Master in the streets.
Like four more Vaklu supporters in the Cantina.
The giant Storm Beast on Malachor.
About a dozen mercenaries on Telos' surface.
5-6 mercenaries as you exit the Kinrath caves (assuming Light Side canon choice).
About 5 salvagers as you exit the Jedi Enclave Ruins.
Nothing mandatory approaches the "hundreds" mark, but if you do away with the "maybe the Exile and her party Sneaked everywhere they went" argument, then the number is definitely in the hundreds.