Playing True Vault Hunter mode now (finally got my copy of BL2 friday last week. 😄) and I have to say, difficulty scaled up quite a bit).
So far, haven't hit a "Diablo 3 Inferno" kind of frustration, tho. My playstyle with Zero has always been snipe snipe, if they come close: drop your ghost and run run then snipe again. lol. So dying is a rarity so far.
Multiplaying has been rife with cheaters/hackers/exploiters, tho. That's the only negative so far in the game.