Smh...
Apocalypse's goal has always been to rule over an Earth populated by the best of the best of mutant kind, and he attempts to achieve that goal by causing conflicts that weed out the weak among society via artificial natural selection. That process takes a long amount of time. It's intrinsic to Apocalypse's storyline that he inevitably conquers the world, in multiple timelines at that, including 616.
In DC I think he'd flourish, actually. Better writers with better vision would help. I see him effecting the evolutionary process on DC Earth and causing the populace to have an increase in metahumans to the point where baseline humans become a minority and the numbers of supervillains and metahuman involved crimes reach catastrophic levels. All from the shadows. Eventually, of course, Batman would discover that someone has been tampering with the human genome and some of Apocalypse's agents get discovered (Dark Beast more than likely). This would get the JLA on his trail and working to counter his efforts which lead to the usual climactic battle, plans being thwarted, and Apocalypse remaining in the shadows to plot another scheme.