Spider-man in New York City wins if we're talking about Otto.
Spider-man in New York City has a chance of winning if we're talking Parker, but stalemate is likeliest,
and Pete is not absolutely adverse to running away if no innocents besides himself are being threatened.
She-Hulk wins in a featureless environment.
You're handicapping Spidey if you take him out of his relatively specialized urban niche.
http://www.comicvine.com/the-spectacular-spider-man-168/4000-65562/
Too bad I don't have the actual "fight" where he casually punched her across the room.
But but but... She Hulk is stronger !!!
Yeah, so are most of Spider-Mans enemies. Like he cares.