It's maybe too early to tell if it's "permanent" but one can make a case that the Living Tribunal's defeat at the hands of 3 beyonders has marred his reputation.
His reputation as Marvel's most powerful being was largely solidified by two feats: his indisputable judgments over the Infinity Gauntlet and his ability to resist the longest against the Heart of the Universe.
That 3 run of the mill beings from a race of thousands/millions killed him suggests the Tribunal's power is mathematically approaching zero when compared with the beyonder race.
The beyonders running roughshod over the MU is fine. But the Tribunal dying off panel in original sin, only to be revealed dying on panel a year after the fact at the hands of 3 beyonders, shatters his reputation.