Despero should take this.
1. Starro Cutting Despero's head didnt finish him so what exactly is WBH going to do. He has almost complete control over his own atomic structure. To the point he has reduced himswlf to a fetus and controlled his aging.
2. Despero in TP is stronger than the combined TP of MMH and Aquaman so above anyone any Hulk has ever resisted.
3.what stops despero's TK (which is actually what his psionic eye beam atyack is) from ripping Hulk's mind apart.
4. Despero is stronger than Supes/MMH/Captain Marvel/ Hourman and powergirl. He's literally faced them all simultainioisly and no sold their combined attacks.
Okay so you have a mindless out of control WB Hulk stomping the living shit out of Despero like no one has ever done in comic history. Does anyone recall the mindless Hulk? Well put him at the strength level of what he was at during HOTM and you get the picture. The last thing Despero would want to do, is completely remove Banner from the Hulk.
I have the utmost respect for Despero, but going H2H with the World Breaker? I have always said the Hulk is largely a two dimensional character, and I could go into detail about the difference between strength and power ...but hand to hand versus a high level Hulk (that is already at WB level, thus taking away the ability to take him out before he sufficiently amps up) is simply not wise.
WBH.
Superman at his best would be able to go blow for blow with the WB. Despero mandhandled Supes, however, as Stoic pointed out, Supes defeated him 1 on 1. I think that Despero can go blow for blow with the Hulk, for some time, but would get drained earlier than Hulk. So he needs the TP and other means to take the win. Even if the TP is only used to calm Hulk down or shut down some of his rage reservers it could do the trick. In a Forum fight a legit tech.