Yes he did bloodied up Hulks nose a little, but it still did nothing to offer up any wearing down of Hulk before that one final blow, but I can see your side of it as not being a one punch situation, and I can see her side as well for it being a one shot since the previous punches had no effect on Hulk.
When Superman ko'ed Thor in the JLA / Avengers crossover with one big punch, that was not a one shot as both combatants beat each over into a state of exhaustion, definitely a wearing down effect there.