If Danjaq/MGM/UA/Sony/ whoever owns Bond now and produces the films decides to go female Bond, the franchise is dead already. Bond's character has evolved over the years, but playboy superspy with varying degrees of ferocity, brutality, suaveness, and drinking & smoking are as integral to his character as sports cars, gadgets, and deformed villains and their henchman.
That's without mentioning two bigger points:
1. It dishonors how Ian Fleming wrote and described his character of James Bond.
2. It ignores the years of variations on Bond themes and characters that were progressive themselves: XXX being Bond's Soviet Union female counterpart in The Spy Who Loved Me, James trying to settle down until Blofeld and Irma Blunt murder Tracy Bond in On Her Majesty's Secret Service, Wei Lin being Bond's Chinese counterpart in Tomorrow Never Dies, Bond not having sex with Olga Kurylenko's Camille Montes and assisting her in stopping General Medrano in Quantum of Solace, and even M becoming a woman in Goldeneye and onward with Judi Dench filling the role instead of another male actor. Moneypenny is now Naomie Harris and not another "white" actress.
Woke themes infested Star Wars, Star Trek, Fox X-Men, and now Phoebe what's her face is trying it with 007. They should all learn from Star Wars, and especially for Bond, that it doesn't make for good movies.