Originally posted by AuraAngel
I suppose that gets some basics out of the way. Ignores the interesting geo-political stuff and the even more interesting religious stuff but hey.
Yea, there is a lot of stuff having to do with kings, nations, poverty, and such as well.
I have not touched UQ Holder since the first issue mostly cause I never read the first series.
While it is in the same universe as Negima, the main character doesn't know that stuff, so I don't think you-as-reader need to either. Some stuff is going to be more shocking if you knew the prior and/or spoil some stuff from Negima (which, btw, once it went full shounen fight, was definitely my favorite series at the time. Clever fights with fast pacing and a wide cast who contributed), but I think you'd probably enjoy it.
It's interesting in that the main characters are all immortal, yet it manages to retain drama despite that.