I will not side with any particular party, I however will put on the table the might that Darkseid will face, if he confronted The Destroyer Armor while it is inhabited by a host:
The Destroyer is lifeless until animated by the life-force of a living being. Once animated, however, the Destroyer is almost invincible. It possesses incalculable strength, near-complete invulnerability, the ability to project immensely powerful bolts of energy/heat/concussive force, control magnetism, manipulate matter; fly, and fire a disintegration beam activated via a visor that can destroy virtually anything. The Destroyer is one of the few non-cosmic characters in the Marvel Universe capable of overpowering and killing Thor, who by his own admission is outmatched.
I have a feeling that even Darkseid would be overmatched here, The Destroyer just seems to be made of sterner stuff than Darkseid.