This can only be a fight if Superman is not a susceptible to Neo's godlike control over the Matrix. We should have Neo just fight Superman on even terms like he did Smith.
If we get Neo out of the matrix he is a blind human against a super powered being. Spite.
If we keep Neo in the Matrix and have Superman successfully integrated into the Matrix then this is a superhuman(supposing he would retain his powers) against a near godlike being. Spite.