I didn't get the feeling he was significantly weakened when he unleashed the HMR blast, because:
a.) We know each of those canisters contained pure cosmic energy collected from multiple planets the A-Wave had destroyed--and Galactus appeared to have absorbed ALL of them.
b.) Prior to Galactus absorbing the canisters, quite a bit of physical damage to his person could be seen--but when he was absorbing the canisters, said damage was nonexistent.
srug