http://www.ign.com/articles/2018/04/22/spider-man-homecoming-sequel-takes-place-around-the-world
What Spidey rogue is a fit for globetrotting? I could kind of see Octavius being some kind of technological genius with pull and influence all over the world, but that’s about it. I don’t see Scorpion or Shocker in London. Oscorp could be an international company I guess since we haven’t seen it in the NY skyline. I’m honestly not sure who they’d go with for this.
Maybe it's a Civil War type deal where he gets pulled by the Avengers for a threat so it happens concurrently with Avengers 3 part 1 and 2, and he uses the time he's not with them to deal with his own problems? That would be kind of cool, except we'd have to have the Iron Spider for the entire movie and I'd rather he have his own suit by now.
Or better yet, maybe he is just on a high school trip and the entire movie is Kraven hunting him around the world. That would be damn cool.