Dr Strange(with Spear of Destiny)vs Spectre no, to easy, Lucifer instead
It's simple Strange with the Spear of Destiny blocks all of Lucifer's attacks even his "I'll wink you out of existence technique" and bashes his brains in with it.
Sound rediculous, think again.
individuals with no mystic training have slapped Spectre around with it, nearly killing him, it is known that the more mystically inclined the wielder the greater still it's power.
So, if dudes without any magic abilities can slap god's wrath around, then imagine it's potential in the hands of earth's sorcerer supreme.
The thing is the Spear carries(in essense) the blood of The Word, third consciousness to come into existence after The Voice spoke, The Voice being the first sound uttered by The Source, which came before both.