As for the whole "not being able to handle the ghosts at full potency" thing. Like a sensible person rather than state "I think this so you're wrong" or "I believe this so HA!" I went back and watched these scenes myself. In the Act 2 finale, Nox is overwhelmed by the spirits all flooding him/her with their power, which is what unleashed the blast Sel says would still deteriorate Nox. Which, while plausible, is a superfluous argument. The real question to ask is not whether that same energy would still harm Nox that way,but rather, are the ghosts still capable of unleashing all that energy in such a way that it damages Nox? To which the answer is no and is WHY Nox can wield it as she does at the End of Act 3, as is obvious, in a more refined and effective manner without burning her body out.
Now, as to Thanaton being tired when we cinematically see Nox bat away his lightning and TK dominate him, etc. It always intrigues me that people seem to act like Nox hadn't just fought Thanaton and was instead coming in when he was already beaten down. Yes Thanaton is tired, why? Because Nox defeatd him through superior Force mastery. This childish notion of "X could only do Y to Z because Z was tired" right after they fought is applying a stipulation caused by X to begin with in this instance. For example, on a more physical plane and one not open to as much interpretation....
Try saying the same ting about say... two MMA fighters and one submitting the other when the one who was victorious was obviously superior the entire fight. "Well, X only submitted him because he was tired!" obviously, we just saw the other out-fight them to GET them there so.... pointless fact, bravo.
And before Sel says something along the lines of... what was it? "Nox had to tire Thanaton out to ragdoll him." first of all game mechanics due to the fact that in the MMO you have to deplete a health bar. Second, if Sel is going to say things are true since she believes them, then I will take my turn if you please.
Obviously at the end of the confrontation Thanaton is winded. What is interesting to note is that there is actually a clue here as to the "tone" of the fight itself, despite us doing it in a game-mechanics fight. Nox, obviously not winded, doesn't just kill Thanaton and be done with. (Obviously able to as well) Instead Nox shows Thanaton their disparity in power by tanking everything he throws at her and stays standing. Now, like Sel's thoughts but with obvious view-able support, these are speculations based on what can be observed by any who watch this cinematic.