Darkstorm Zero
Master of all Decepticons
Ok, it seems some people here are having trouble articulating the real issues at play here. Let me see if i can't clear up some misconceptions.
The most contentious issue at play is the TOW Bombs, and whether or not they can play a role in the outcome of this match. Ok, so in the first Matrix movie, we see the Sentinels often have to be avoided by the Zion ships by powering down their systems and if needs be, charging an Electromagnetic Pulse device. It's demonstrated on screen that if a ship's primary systems are powered down, a Sentinel can't seem to confirm a target, even with numerous sensors at play, including visual, audio, or radar sensor sweeps. But the Machine's onboard AIs are not just idle, they are always learning we can assume. So, after incurring enough losses from this bait and EMP tactic Zion has been using for who knows how long, the machines develop the counter in question - the TOW bombs.
Now, these TOW bombs are thrown from outside the EMP range, though not necessarily outside of detection range, as demonstrated in the second movie. It wasn't necessarily clear if the Nebuchadnezzar was powered down when hit by the TOW bomb thrown at it, if it wasn't well then it should have been easy enough to detect and hit by the bomb's onboard rudimentary version of an AI (because the machines certainly wouldn't want to sacrifice fully functioning AI programs in suicide weapons, if Animatrix is anything to believe.) If the Nebuchadnezzar was powered down when the TOW bomb found it though, that changes the situation slightly, as we then have no way of knowing how it could track the ship as a target. If the TOWs had upgraded detection systems and better analysis capability, then it makes no sense why the other combat machines like the Sentinels didn't also receive the upgrade, especially considering the Sentinels are designed for combat at much closer range.
All that said, the crux of the argument is this - given what we know of these TOW bombs, can they target individual humans a like they do ships? My answer... unfortunately has to be a no. They were not designed and created to do that. They were designed as a countermeasure to the EMP. The logic doesn't follow that they would be used to target individual humans directly. Certainly humans would be killed via collateral damage and proximity to their detonations, but their primary purpose was to take out the ships. That being said, an argument COULD be made that Dr. Octopus's tentacles could have enough mass and power generation to be considered a viable target for the TOW's sensors to track, in which case, could Octopus's tentacle arms render him vulnerable to a TOW strike? I dunno, possibly. I couldn't say with any reasonable degree of certainty the tentacles provide enough mass and power to be noticable to a TOW's sensors to track as a viable target, but it's much more probable than a TOW targeting an ordinary human being with no additional mass and electrical power sources attached to their spine.
Anyway, that's my two cents, and it is still relatively speculative on my part, so you can take it with a grain of salt if you like, but I hope my words give a little more nuanced context to Thinkerer's argument and it helps.