Originally posted by willRules
I thought that on some fundamental, unexplained level the 616 was just more important. Possibly it's simply because it's the main universe from which our stories our based.
That may have been "proven" in continuity, but, I know for a fact that originally, the term "Universe 616" was chosen in "Excalibur" to refrenence the fact that "our" Marvel Universe was just one of many, many others: not more special, or powerful, or "real," it's just the one we read about. This was to distinguish it from the DC "Earth One," versus "Earth Two" nonsense. At heart, it's about Marvel's more "lifelike" stories versus the "mythological" DC stories.
But I wouldn't doubt at all you could dredge up evidence since then of some ridiculous cosmic threat proving that 616 Marvel is more pertinent than the others.