I'm pretty certain Pym will get his day on the big screen, partly due to the Ant-Man film that's in the works. Though I do hope they don't do the "three Ant-Men" script that was rumored: Pym in the 60's, Lang in the 80s-90s, and O'Grady in the modern days. Pym is a good enough character to work with and a well cast Janet will do wonders anyway.
If the second film has to be more "personal", you don't have to look any further than Ultron. He's easily the most pervasive threat to the Avengers and certainly a more personal one to the team at large.